Frontispiece: Regiodivergent Catalysis: A Powerful Tool for Selective Catalysis

Engineering of Enzymes for Selective Catalysis

Naturally occurring enzymes are truly remarkable catalysts. However, many are not suitable for practical synthetic chemistry because of poor substrate or product selectivity. This review highlights recent advances in engineering enzymes for selective catalysis. Selected topics include altering substrate specificity, altering substrate and product selectivity, engineering enzymes that catalyze c...

Infrared spectroscopy via substrate-integrated hollow waveguides: a powerful tool in catalysis research.

Substrate-integrated hollow waveguides (iHWG) represent an innovative generation of photon conduits, which can simultaneously serve as highly miniaturized gas cells with low sample volume. In this communication, we introduce a novel concept for analyzing the performance of catalysts via infrared gas phase analysis based on iHWGs. Due to rapid gas exchange and sample transient times within the i...

N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable sca...

Homogeneous Catalysis Homogeneous Catalysis

Selective and efficient synthesis of 3-indolyl-2-oxindoles under catalysis of LiClO4

An efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. The syntheses were achieved selectively under catalysis of LiClO4 whereby the products were obtained purely.